Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore

• Published in: Oncotarget Vol. 12; no. 9; pp. 891 - 906
• Main Authors: Paradkar, Sateja, Herrington, James, Hendricson, Adam, Hewawasam, Piyasena, Plummer, Mark, Hoyer, Denton, Sundaram, Ranjini K., Surovtseva, Yulia V., Bindra, Ranjit S.
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 27.04.2021
• Subjects: Research Paper; mibefradil; alternative non-homologous end joining; glioblastoma; DNA repair; radiosensitizers

Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system with a dismal prognosis. Locoregional failure is common despite high doses of radiation therapy, which has prompted great interest in developing novel strategies to radiosensitize these cancers. Our group pre...