The effect of ranitidine, cimetidine or famotidine on low‐dose post‐prandial alcohol absorption

• Published in: Alimentary pharmacology & therapeutics Vol. 5; no. 3; pp. 263 - 272
• Main Authors: FRASER, A. G., PREWETT, E. J., HUDSON, M., SAWYERR, A. M., ROSALKI, S. B., POUNDER, R. E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1991; Blackwell
• Subjects: Adult; Biological and medical sciences; Cimetidine - administration & dosage; Cimetidine - pharmacology; Digestive system; Double-Blind Method; Eating; Ethanol - blood; Ethanol - metabolism; Famotidine - administration & dosage; Famotidine - pharmacology; Humans; Intestinal Absorption - drug effects; Male; Medical sciences; Pharmacology. Drug treatments; Ranitidine - administration & dosage; Ranitidine - pharmacology; Human; Drug alcohol interaction; Absorption; Ethanol; H2 receptor; Alcoholemia; Antiulcer agent; Normal; Antihistaminic
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.1991.tb00027.x

SUMMARY Plasma alcohol concentration following oral ingestion of 0.3 g/kg of alcohol (ethyl alcohol), one hour after an evening meal, was measured in four groups of 12 healthy subjects. Each group had a control study and a repeat study after 7 days dosing with either placebo or an H2‐receptor antagonist (300 mg ranitidine nocte, 800 mg cimetidine nocte, or 40 mg famotidine nocte). There was no significant difference between the control and post‐dosing studies in the integrated 4‐h plasma alcohol concentration, peak plasma alcohol concentration, or time to reach peak alcohol concentration. This study shows that post‐prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine.