Advances in high-resolution mass spectrometry techniques for analysis of high mass-to-charge ions

A major challenge in modern mass spectrometry (MS) is achieving high mass resolving power and accuracy for precision analyses in high mass-to-charge (m/z) regions. To advance the capability of MS for increasingly demanding applications, understanding limitations of state-of-the-art techniques and th...

Full description

Saved in:
Bibliographic Details
Published inMass spectrometry reviews Vol. 42; no. 6; pp. e21790 - 2445
Main Authors Lai, Yin-Hung, Wang, Yi-Sheng
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2023
Subjects
Macromolecules
Mass spectroscopy
Proteomics
high-resolution mass spectrometry
quadrupole
top-down proteomics
time-of-flight
native MS
high mass-to-charge
Fourier-transform
Online AccessGet full text

Cover

More Information
Summary:A major challenge in modern mass spectrometry (MS) is achieving high mass resolving power and accuracy for precision analyses in high mass-to-charge (m/z) regions. To advance the capability of MS for increasingly demanding applications, understanding limitations of state-of-the-art techniques and their status in applied sciences is essential. This review summarizes important instruments in high-resolution mass spectrometry (HRMS) and related advances to extend their working range to high m/z regions. It starts with an overview of HRMS techniques that provide adequate performance for macromolecular analysis, including Fourier-transform, time-of-flight (TOF), quadrupole-TOF, and related data-processing techniques. Methodologies and applications of HRMS for characterizing macromolecules in biochemistry and material sciences are summarized, such as top-down proteomics, native MS, drug discovery, structural virology, and polymer analyses.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0277-7037
1098-2787
DOI:10.1002/mas.21790