Association of aberrant brain network dynamics with gut microbial composition uncovers disrupted brain-gut-microbiome interactions in irritable bowel syndrome: Preliminary findings

• Published in: European journal of neurology Vol. 30; no. 11; pp. 3529 - 3539
• Main Authors: Yang, Lin, Liu, Guangyao, Li, Shan, Yao, Chaofan, Zhao, Ziyang, Chen, Nan, Zhang, Pengfei, Shang, Yingying, Wang, Yin, Zhang, Dekui, Tian, Xiaozhu, Zhang, Jing, Yao, Zhijun, Hu, Bin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2023
• Subjects: Abnormalities; Brain; Brain mapping; Composition; Digestive system; Feces; Functional magnetic resonance imaging; Gene sequencing; Intestinal microflora; Intestine; Irritable bowel syndrome; Magnetic resonance imaging; Microbiomes; Microbiota; Microorganisms; Neural networks; Neuroimaging; Pathogenesis; rRNA 16S; dynamic functional connectivity; brain-gut-microbiome axis; gut microbiome; irritable bowel syndrome; resting-state functional MRI

Growing evidence suggests that abnormalities in brain-gut-microbiome (BGM) interactions are involved in the pathogenesis of irritable bowel syndrome (IBS). Our study aimed to explore alterations in dynamic functional connectivity (DFC), the gut microbiome and the bidirectional interaction in the BGM...