Two symmetrical unsaturated acids isolated from Viscum album

In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 – 11). Their structures were confirmed on t...

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Published inChinese journal of natural medicines Vol. 17; no. 2; pp. 145 - 148
Main Authors CAO, Duo, WANG, Li-Qing, HAN, Xiao-Min, GUAN, Hui-Rui, LEI, Meng, WEI, Ya-Hui, CHENG, Liang, YANG, Pei-Ming, SUN, Zheng-Liang, GAO, Wen, DAI, Jia-Kun
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.02.2019
Subjects
Acetylene - chemistry
Antioxidant activity
Antioxidants - chemistry
Antioxidants - pharmacology
Biphenyl Compounds - chemistry
Molecular Structure
Picrates - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Symmetrical unsaturated acid
Viscum album
Viscum album - chemistry
Xanthine Oxidase - chemistry
Symmetrical unsaturated acid
Antioxidant activity
Viscum album
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Summary:In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 – 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L−1, and the SC50 of 4.34 and 8.22 μmol·L−1, respectively.
Bibliography:ObjectType-Article-1
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ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30016-0