Protective effect of collagen derivates on the ulcerative lesions caused by oral administration of ethanol

• Published in: Journal of medicinal food Vol. 10; no. 1; pp. 154 - 158
• Main Authors: Castro, G.A, Sgarbieri, V.C, Carvalho, J.E, Tinti, S.V, Possenti, A
• Format: Journal Article
• Language: English
• Published: United States 01.03.2007
• Subjects: animal models; Animals; anti-ulcer activity; Anti-Ulcer Agents - administration & dosage; beef cattle; Carbenoxolone - administration & dosage; Cattle; collagen; Collagen - administration & dosage; Collagen - chemistry; dosage; dose response; Dose-Response Relationship, Drug; ethanol; Ethanol - toxicity; Hydrolysis; intestinal mucosa; Male; oral administration; peptic ulcers; protective effect; protein hydrolysates; Rats; Rats, Wistar; Stomach Ulcer - chemically induced; Stomach Ulcer - pathology; Stomach Ulcer - prevention & control; Swine
• ISSN: 1096-620X; 1557-7600
• DOI: 10.1089/jmf.2006.262

The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions.