Bcl-2 and MALT1 Genes are not involved in the oncogenesis of uterine tumors resembling ovarian sex cord tumors

• Published in: Pathology oncology research Vol. 13; no. 2; pp. 153 - 156
• Main Authors: Sitic, Sanda, Korac, Petra, Peharec, Petra, Zovko, Gojko, Perisa, Marija Milkovic, Gasparov, Slavko
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.2007
• Subjects: 12E7 Antigen; Actins - genetics; Actins - metabolism; Aged; Antigens, CD - genetics; Antigens, CD - metabolism; Caspases - genetics; Caspases - physiology; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - metabolism; Cell Differentiation - physiology; Female; Gene Expression Regulation, Neoplastic; Genetics; Humans; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins - genetics; Neoplasm Proteins - physiology; Neprilysin - genetics; Neprilysin - metabolism; Oncology; Pathology; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - physiology; Sex Cord-Gonadal Stromal Tumors - genetics; Sex Cord-Gonadal Stromal Tumors - pathology; Sex Cord-Gonadal Stromal Tumors - physiopathology; Translocation, Genetic - genetics; Tumors; Uterine Neoplasms - genetics; Uterine Neoplasms - pathology; Uterine Neoplasms - physiopathology; Uterus - pathology; Uterus - physiopathology; Vimentin - genetics; Vimentin - metabolism
• ISSN: 1219-4956; 1532-2807
• DOI: 10.1007/BF02893492

Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare entities. They were described by Clement and Scully in 1976 who classified them into groups I and II. Group I comprises typical endometrial stromal neoplasms with focal areas resembling ovarian sex cord elements and group II are predominantly or completely composed of ovarian sex cord-like elements. We report a case of UTROSCT type II with cytogenetic analysis. The tumor occurred in a 76-year-old woman who presented with vaginal bleeding. The tumor was lobulated, firm, yellow and histologically composed of sex cord-like elements. Tumor cells expressed vimentin, CD10, CD99 and alpha-actin. Cytogenetic analysis in a previously reported case detected translocation t(4;18)(q21.1;q21.3) in the majority of cells. Bcl-2 and MALT1 genes are located at or near the translocation breakpoints, and the aim of this study was to determine whether these genes were involved in chromosomal translocation or tumorigenesis. We did not find IgH translocation or the most common MALT translocations. Bcl-2 was also not involved in this oncogenesis.