Correlation of matrix metalloproteinase-3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration

The purpose of the present study is to analyze the expression of matrix metalloproteinase-3 (MMP-3), magnetic resonance imaging (MRI) grading and histopathological alterations of the intervertebral disc (IVD) for correlations with each other and with the age, gender and low back pain duration of the...

Full description

Saved in:
Bibliographic Details
Published inTurkish neurosurgery Vol. 23; no. 4; pp. 427 - 433
Main Authors Canbay, Suat, Turhan, Nesrin, Bozkurt, Melih, Arda, Kemal, Caglar, Sukru
Format Journal Article
LanguageEnglish
Published Turkey 2013
Subjects
Adult
Age Factors
Aged
Aging - metabolism
Female
Humans
Image Processing, Computer-Assisted
Immunohistochemistry
Intervertebral Disc Degeneration - enzymology
Intervertebral Disc Degeneration - pathology
Linear Models
Low Back Pain - etiology
Magnetic Resonance Imaging
Male
Matrix Metalloproteinase 3 - biosynthesis
Middle Aged
Sex Factors
Online AccessGet full text

Cover

More Information
Summary:The purpose of the present study is to analyze the expression of matrix metalloproteinase-3 (MMP-3), magnetic resonance imaging (MRI) grading and histopathological alterations of the intervertebral disc (IVD) for correlations with each other and with the age, gender and low back pain duration of the patients who had undergone operations for lumbar disc herniation (LDH). Forty-two patients were admitted to our clinic with signs of LDH and underwent surgery for LDH at 48 IVD levels. In all cases, specimens for histological and immunohistochemical analyses were removed from the IVD space. Lumbar IVD degeneration on MRI of the 48 IVDs from which surgical specimens had been obtained was classified into five grades using the Pfirrmann classification. In the degenerated IVD, the expression of MMP-3, MRI grading and histopathological alterations of the IVD displayed significant correlation. Increased age is closely related with aforementioned alterations. There was no correlation between MMP-3 expression and age, gender and duration of the pain. For evaluating and treating IVD degeneration, MRI is a good and non-invasive diagnostic tool to determine the severity of degeneration. MMP-3 may be a therapeutic target of the degenerated IVD.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1019-5149
DOI:10.5137/1019-5149.JTN.7459-12.0