Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips

To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were di...

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Published inBiomedical and environmental sciences Vol. 29; no. 7; pp. 539 - 543
Main Authors SHI, Xiao Wei, SHI, Bo Hui, LYU, Ai Li, ZHANG, Feng, ZHOU, Tian Tian, GUO, Xiong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2016
Department of Pediatrics, The First Affiliated Hospital of the Medical Col ege of Xi’an Jiaotong University, Xi’an 710061, Shannxi, China%Department of 0ncosurgery, The First Affiliated Hospital of the Medical College of Xi’an Jiaotong University, Xi’an 710061, Shannxi, China
Subjects
Adult
Case-Control Studies
Cluster Analysis
CpG Islands
DNA Methylation
Female
Genetic Variation
Genome-Wide Association Study
Humans
Kashin-Beck Disease - genetics
Middle Aged
Oligonucleotide Array Sequence Analysis
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Summary:To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were differentially
Bibliography:To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were differentially
11-2816/Q
SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2016.072