Increased reactivity to histamine in the coronary vascular system of the guinea-pig after endotoxin

Histamine produced a dose-dependent increase in heart rate, myocardial contractility and coronary flow in the isolated guinea-pig heart using a modified Langendorff procedure. Intraperitoneal treatment of the guinea pigs with E. coli endotoxin, 4 days prior to the experiment, enhanced the positive c...

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Bibliographic Details
Published inAgents and actions Vol. 27; no. 1-2; p. 158
Main Authors van Heuven-Nolsen, D, Ten Have, G A, Nijkamp, F P
Format Journal Article
LanguageEnglish
Published Switzerland 01.04.1989
Subjects
Animals
Coronary Circulation - drug effects
Endotoxins - toxicity
Guinea Pigs
Heart Rate - drug effects
Histamine - pharmacology
Male
Myocardial Contraction - drug effects
Receptors, Histamine - physiology
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Summary:Histamine produced a dose-dependent increase in heart rate, myocardial contractility and coronary flow in the isolated guinea-pig heart using a modified Langendorff procedure. Intraperitoneal treatment of the guinea pigs with E. coli endotoxin, 4 days prior to the experiment, enhanced the positive chronotropic and flow-increasing effect of histamine. The increased response to histamine appeared to be H1-receptor mediated, the positive chronotropic response is attributed to H2-receptors. These results indicate that bacterial endotoxin increases the reactivity of the coronary vascular system of the guinea-pig to histamine.
ISSN:0065-4299
DOI:10.1007/BF02222226