Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II)

A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 micrograms/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basi...

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Bibliographic Details
Published inExperientia Vol. 39; no. 1; p. 74
Main Authors Avner, E D, Sweeney, Jr, W E, Ellis, D
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1983
Subjects
Animals
Cisplatin
Kidney - embryology
Mice
Models, Biological
Organ Culture Techniques
Polycystic Kidney Diseases - chemically induced
Polycystic Kidney Diseases - pathology
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Summary:A new experimental model of renal tubular cyst formation has been developed in metanephric organ culture. The addition of cis-dichlorodiammineplatinum (II), 50 micrograms/ml, to culture medium induces cystic changes during in vitro nephrogenesis. The model has particular utility in the study of basic mechanisms underlying renal tubular cystic changes, as well as the mechanisms by which nephrotoxins may mediate renal tubular injury.
ISSN:0014-4754
DOI:10.1007/BF01960636