The adhesin structures involved in the adherence of group B streptococci to human vaginal cells

The adherence of group B streptococci (GBS) of serotypes Ia, II and III to human vaginal cells was studied in vitro. The adherence was not dependent on the viability of bacteria; killing of GBS by UV irradiation or glutaraldehyde treatment did not inhibit the adherence. Killing of GBS by heating to...

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Bibliographic Details
Published inFolia microbiologica Vol. 31; no. 5; p. 394
Main Authors Bulgakova, T N, Grabovskaya, K B, Rýc, M, Jelínková, J
Format Journal Article
LanguageEnglish
Published United States 01.01.1986
Subjects
Bacterial Adhesion - drug effects
Bacterial Adhesion - radiation effects
Female
Glutaral - pharmacology
Hot Temperature
Humans
Neuraminidase - pharmacology
Pepsin A - pharmacology
Streptococcus agalactiae - pathogenicity
Trypsin - pharmacology
Ultraviolet Rays
Vagina - microbiology
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Summary:The adherence of group B streptococci (GBS) of serotypes Ia, II and III to human vaginal cells was studied in vitro. The adherence was not dependent on the viability of bacteria; killing of GBS by UV irradiation or glutaraldehyde treatment did not inhibit the adherence. Killing of GBS by heating to 56 degrees C for 1 h led to a pronounced decrease of adherence, demonstrating the thermosensitivity of the GBS structures involved. The protein nature of these structures was proved by a significant reduction of adherence after pretreatment of GBS with trypsin or pepsin. Pretreatment of GBS with sialidase had no influence on the adherence. Such a pretreatment of vaginal cells caused an increase of adherence showing that the receptors on epithelial cells may be partly masked by sialic acid.
ISSN:0015-5632
DOI:10.1007/BF02936605