Malignant Triton tumor. A case with protean histopathological patterns

A case of malignant Triton tumor occurring in the leg of a 48-year-old woman with neurofibromatosis (von Recklinghausen's disease) is presented. The neoplasm was composed mainly of spindle-shaped cells forming interlacing fascicles with areas of massive necrosis. The important feature in this n...

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Bibliographic Details
Published inThe American journal of dermatopathology Vol. 14; no. 3; p. 255
Main Authors Kiryu, H, Urabe, H
Format Journal Article
LanguageEnglish
Published United States 01.06.1992
Subjects
Actins - analysis
Cell Nucleus - pathology
Cytoplasm - ultrastructure
Female
Humans
Leg
Middle Aged
Mitosis
Muscles - pathology
Myoglobin - analysis
Neoplasms, Multiple Primary - pathology
Neurilemmoma - pathology
Neurofibromatosis 1 - pathology
S100 Proteins - analysis
Skin Neoplasms - pathology
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Summary:A case of malignant Triton tumor occurring in the leg of a 48-year-old woman with neurofibromatosis (von Recklinghausen's disease) is presented. The neoplasm was composed mainly of spindle-shaped cells forming interlacing fascicles with areas of massive necrosis. The important feature in this neoplasm was the presence of rhabdomyoblastic cells admixed with other cellular components. In addition, variable histologic features including solid, myxomatous, hemangiomatous, hemangiopericytomatous, epithelioid, and lymphomatous areas were identified. This variety has been recognized in malignant schwannomas, but not in malignant Triton tumors. There were discrete foci with each predominant histologic feature shown in a map of the neoplasm in which the distribution of those components is demonstrated based on the histology and immunohistochemistry. Satisfactory biopsy specimens are necessary for accurate diagnosis of malignant Triton tumor.
ISSN:0193-1091
DOI:10.1097/00000372-199206000-00013