Genetic and cytogenetic changes in acute lymphoblastic leukemia

In recent years, a number of non-random chromosomal alterations have been identified in specific populations of acute lymphoblastic leukemic cells of either B-cell or T-cell lineage. The most frequently involved chromosomal sites are 1q, 4q, 6q, 7q, 8q, 9p, 9q, 10q, 11p, 12p, 14q, 19p and 22q. Genes...

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Bibliographic Details
Published inMedical oncology and tumor pharmacotherapy Vol. 5; no. 4; p. 211
Main Authors Ahuja, H G, Cline, M J
Format Journal Article
LanguageEnglish
Published England 01.01.1988
Subjects
Chromosome Aberrations
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
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Summary:In recent years, a number of non-random chromosomal alterations have been identified in specific populations of acute lymphoblastic leukemic cells of either B-cell or T-cell lineage. The most frequently involved chromosomal sites are 1q, 4q, 6q, 7q, 8q, 9p, 9q, 10q, 11p, 12p, 14q, 19p and 22q. Genes located near frequent breakpoints include c-myc, c-abl and the genes for the T-cell alpha and beta receptors. In addition, approximately 20 other genes potentially involved in the leukemic process are located near less frequently encountered, but consistent, chromosomal breakpoints.
ISSN:0736-0118
DOI:10.1007/BF03003187