Sleep Impairment and Psychological Distress among Patients with Inflammatory Bowel Disease—beyond the Obvious

• Published in: Journal of clinical medicine Vol. 9; no. 7; p. 2304
• Main Authors: Gîlc-Blanariu, Georgiana-Emmanuela, Ștefnescu, Gabriela, Trifan, Anca Victorița, Moscalu, Mihaela, Dimofte, Mihail-Gabriel, Ștefnescu, Cristinel, Drug, Vasile Liviu, Afrsnie, Vlad-Adrian, Ciocoiu, Manuela
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.07.2020; MDPI
• Subjects: Anxiety; Clinical medicine; Colonoscopy; Confidence intervals; Crohns disease; Ethics; Hospitals; Inflammatory bowel disease; Pathogenesis; Patients; Questionnaires; Sleep; Statistical analysis; Romania
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm9072304

Background: A healthy sleep–wake cycle is fundamental for regulating immune function. Sleepiness and fatigue are often manifestations of chronic inflammatory disorders, such as inflammatory bowel disease (IBD), potentially influencing the course of the disease. Our aim was to characterize sleep impairment in patients with IBD and to identify potential associated factors. Methods: We conducted a single-center prospective case control study including IBD patients and healthy controls. We evaluated clinical and biochemical parameters, sleep impairment through Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression through Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: In total, 110 patients with IBD and 66 healthy controls were included. Patients with IBD had a significantly altered sleep quality compared to the control group (p < 0.001), with sleep impairment also occurring for patients in remission (median PSQI = 7), but without significant differences between ulcerative colitis and Crohn’s disease. However, PSQI was correlated with disease activity scores only for ulcerative colitis and not for Crohn’s disease. Among patients with increased PSQI, only 30.19% used sleep medication. Sleep impairment was significantly correlated with altered psychological status (p < 0.01) and the presence of extraintestinal manifestations (p = 0.0172). Conclusions: Sleep impairment is frequent among patients with IBD, is associated with psychological distress and several disease-related parameters and should be routinely evaluated, at least in several IBD patient subgroups, to improve disease management.