Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces
A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG range...
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| Published in | Biomedical and environmental sciences Vol. 28; no. 5; pp. 383 - 387 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.05.2015
Col ege of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, China%Tongji Medical Col ege, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0895-3988 2214-0190 |
| DOI | 10.3967/bes2015.054 |
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| Abstract | A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males. |
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| AbstractList | A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium (UCd) for renal dysfunction as benchmark dose low (BMDL). The urinary N-acetyl-β-D-glucosaminidase (UNAG) was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18 μg/g creatinine (cr) to 4.26 μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses (BMR) of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males. A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males. A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium (UCd) for renal dysfunction as benchmark dose low (BMDL). The urinary N-acetyl-β-D-glucosaminidase (UNAG) was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18 μg/g creatinine (cr) to 4.26 μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses (BMR) of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium (UCd) for renal dysfunction as benchmark dose low (BMDL). The urinary N-acetyl-β-D-glucosaminidase (UNAG) was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18 μg/g creatinine (cr) to 4.26 μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses (BMR) of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males. |
| Author | KE Shen KE Qin Mei JIA Wen Jing CHENG Xi Yu LI Hao ZHANG Jie Ying LUO Hui Fang HE Jin Sheng CHEN Zhi Nan |
| AuthorAffiliation | college of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, China Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China |
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| Copyright | 2015 The Editorial Board of Biomedical and Environmental Sciences Copyright © 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Notes | A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males. 11-2816/Q ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 23 |
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| References | Suwazono, Nogawa, Uetani (bib3) 2011; 214 MOHC (Ministry of Health of the People's Republic of China) (bib8) 1998 Kobayshi, Suwazono, Uetani (bib2) 2006; 101 Shao, Jin, Wu (bib6) 2007; 20 Jin, Wu, Tang (bib5) 2004; 17 Suwazono, Nogawa, Uetani (bib4) 2011; 111 EC (European Commission). Scientific Committee on Toxicity, Ecotoxicity and the Environment (CSTEE). Opinion on the results of the risk assessment of cadmium metal human health, cadmium oxide human health. C7/VR/csteeop/Cdmet-ox hh/080104 D(04). 2004. Adopted by the CSTEE during the 41st plenary meeting of 8 January 2004. Ke, Qiao (bib1) 2013 Sakuragi, Takahashi, Hoshuyama (bib7) 2012; 85 Chen, Gan, Zhu (bib9) 2013; 55 |
| References_xml | – volume: 20 start-page: 460 year: 2007 end-page: 464 ident: bib6 article-title: Application of benchmark dose (BMD) in estimating biological exposure limit (BEL) to cadmium publication-title: Biomed Environ Sci – year: 2013 ident: bib1 publication-title: Cadmium toxicity is much more terrible than the beast: Preliminary studies of adverse health effects of cadmium pollution in China – volume: 214 start-page: 175 year: 2011 end-page: 178 ident: bib3 article-title: Reassessment of the threshold of urinary cadmium by using hybrid approach in a cadmium non-polluted area in Japan publication-title: Int J Hyg Environ Health – year: 1998 ident: bib8 publication-title: Standard of China, GB/T 17221-1998, Discriminant standard for health hazard area caused by environmental cadmium pollution – volume: 101 start-page: 401 year: 2006 end-page: 406 ident: bib2 article-title: Estimation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, β publication-title: Environ Res – volume: 17 start-page: 525 year: 2004 end-page: 530 ident: bib5 article-title: Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China publication-title: Bio Metals – volume: 111 start-page: 312 year: 2011 end-page: 314 ident: bib4 article-title: Application of the hybrid approach to the benchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted areas in Japan publication-title: Environ Res – volume: 85 start-page: 941 year: 2012 end-page: 950 ident: bib7 article-title: Variation in benchmark dose (BMD) and the 95% lower confidence limit of benchmark dose (BMDL) among general Japanese populations with no anthropogenic exposure to cadmium publication-title: Int Arch Occup Environ Health – reference: EC (European Commission). Scientific Committee on Toxicity, Ecotoxicity and the Environment (CSTEE). Opinion on the results of the risk assessment of cadmium metal human health, cadmium oxide human health. C7/VR/csteeop/Cdmet-ox hh/080104 D(04). 2004. Adopted by the CSTEE during the 41st plenary meeting of 8 January 2004. – volume: 55 start-page: 592 year: 2013 end-page: 595 ident: bib9 article-title: Benchmark dose for estimation of cadmium reference level for osteoporosis in a Chinese female population publication-title: Food Chem Toxicol |
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| SubjectTerms | Adult Aged Aged, 80 and over Cadmium - toxicity Cadmium - urine China - epidemiology Creatinine - urine Dose-Response Relationship, Drug Environmental Pollutants - toxicity Environmental Pollutants - urine Female Humans Kidney Diseases - chemically induced Male Middle Aged Population Surveillance 中国 人群 估计 低剂量 基准 大样本 尿镉 肾功能不全 |
| Title | Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces |
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