Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces

• Published in: Biomedical and environmental sciences Vol. 28; no. 5; pp. 383 - 387
• Main Authors: KE, Shen, KE, Qin Mei, JIA, Wen Jing, CHENG, Xi Yu, LI, Hao, ZHANG, Jie Ying, LUO, Hui Fang, HE, Jin Sheng, CHEN, Zhi Nan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2015; Col ege of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, China%Tongji Medical Col ege, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China
• Subjects: Adult; Aged; Aged, 80 and over; Cadmium - toxicity; Cadmium - urine; China - epidemiology; Creatinine - urine; Dose-Response Relationship, Drug; Environmental Pollutants - toxicity; Environmental Pollutants - urine; Female; Humans; Kidney Diseases - chemically induced; Male; Middle Aged; Population Surveillance; 中国; 人群; 估计; 低剂量; 基准; 大样本; 尿镉; 肾功能不全; China
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2015.054

A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.