Satellite Associations in Down Syndrome

The association of acrocentric chromosomes by their satellites, referred as satellite associations (SAs), is implicated as a cause for non-disjunction and hence an etiological factor for Down syndrome. The present study compares the frequency of SAs observed in 30 children with Down syndrome and the...

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Bibliographic Details
Published inInternational journal of human genetics Vol. 10; no. 1-3; pp. 101 - 104
Main Authors Yashwanth, Radhakrishnan, Chandra, Nallathambi, Gopinath, P.M.
Format Journal Article
LanguageEnglish
Published Routledge 01.03.2010
Subjects
Acrocentric Chromosomes
Down Syndrome
NOR
Satellite Associations
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Summary:The association of acrocentric chromosomes by their satellites, referred as satellite associations (SAs), is implicated as a cause for non-disjunction and hence an etiological factor for Down syndrome. The present study compares the frequency of SAs observed in 30 children with Down syndrome and their parents to that seen in 16 healthy children and their parents. Silver (Ag-NOR) stained metaphases showed statistically significant increase in SAs in children with DS, compared to controls. Satellite associations were found to be also significantly increased in either parent with DS offspring. Two patients with Robertsonian translocation showed decreased SAs. This study supports the hypothesis that an increased tendency for satellite associations is an indicator for non-disjunction.
ISSN:0972-3757
2456-6330
DOI:10.1080/09723757.2010.11886092