Prevention of recurrent acute pancreatitis in patients with severe hypertriglyceridemia: value of regular plasmapheresis

The association between acute pancreatitis and severe hypertriglyceridemia has long been recognized. We report two cases of severe primary hypertriglyceridemia (types 1 and V) with recurrent acute pancreatitis. In both patients, observance of appropriate diet and drug therapy was insufficient. Recur...

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Bibliographic Details
Published inPancreas Vol. 13; no. 1; p. 96
Main Authors Piolot, A, Nadler, F, Cavallero, E, Coquard, J L, Jacotot, B
Format Journal Article
LanguageEnglish
Published United States 01.07.1996
Subjects
Acute Disease
Adult
Cholesterol - blood
Female
Humans
Hyperlipoproteinemia Type I - blood
Hyperlipoproteinemia Type I - complications
Hyperlipoproteinemia Type I - therapy
Hyperlipoproteinemia Type V - blood
Hyperlipoproteinemia Type V - complications
Hyperlipoproteinemia Type V - therapy
Hypertriglyceridemia - complications
Hypertriglyceridemia - therapy
Male
Pancreatitis - etiology
Pancreatitis - prevention & control
Plasmapheresis
Recurrence
Triglycerides - blood
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Summary:The association between acute pancreatitis and severe hypertriglyceridemia has long been recognized. We report two cases of severe primary hypertriglyceridemia (types 1 and V) with recurrent acute pancreatitis. In both patients, observance of appropriate diet and drug therapy was insufficient. Recurrent episodes of pancreatitis were precipitated by dietary fat or alcohol abuse. A plasmapheresis was performed every 4 weeks to decrease the incidence of pancreatitis. It appears that plasmapheresis is a safe and highly effective method for quickly removing serum triglycerides. Moreover, plasma-pheresis may be useful for preventing acute pancreatitis.
ISSN:0885-3177
DOI:10.1097/00006676-199607000-00013