Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

Gonadotropin-releasing hormone (GnRH), having a highly conserved structure across mammalian species, plays a pivotal role in the control of the neuroendocrine events and the inherent sexual behaviors essential for reproductive function. Recent advances in molecular genetic technology have contribute...

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Bibliographic Details
Published inBehavior genetics Vol. 26; no. 3; p. 241
Main Authors Sagrillo, C A, Grattan, D R, McCarthy, M M, Selmanoff, M
Format Journal Article
LanguageEnglish
Published United States 01.05.1996
Subjects
Animals
Brain - physiology
Brain Mapping
Estrus - genetics
Female
Gene Expression - physiology
Gonadotropin-Releasing Hormone - genetics
Hormones - physiology
Humans
Male
Neurotransmitter Agents - physiology
Receptors, LHRH - genetics
Reproduction - genetics
Sexual Behavior, Animal - physiology
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Summary:Gonadotropin-releasing hormone (GnRH), having a highly conserved structure across mammalian species, plays a pivotal role in the control of the neuroendocrine events and the inherent sexual behaviors essential for reproductive function. Recent advances in molecular genetic technology have contributed greatly to the investigation of several aspects of GnRH physiology, particularly steroid hormone and neurotransmitter regulation of GnRH gene expression. Behavioral studies have focused on the actions of GnRH in steroid-sensitive brain regions to understand better its role in the facilitation of mating behavior. To date, however, there are no published reports which directly correlate GnRH gene expression and reproductive behavior. The intent of this article is to review the current understanding of the way in which changes in GnRH gene expression, and modifications of GnRH neuronal activity, may ultimately influence reproductive behavior.
ISSN:0001-8244
DOI:10.1007/BF02359383