Expression of intercellular adhesion molecule-1 and prognosis in colorectal cancer

Intercellular adhesion molecule-1 (ICAM-1) is a 90-kDa cell surface glycoprotein and is known to be a member of the immunoglobulin gene superfamily of adhesion molecules. It has been suggested that ICAM-1 expression on cancer cells might have a role as a suppressor of tumor progression under the hos...

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Published inOncology reports Vol. 9; no. 3; p. 511
Main Authors Maeda, Kiyoshi, Kang, Soon-Myoung, Sawada, Tetsuji, Nishiguchi, Yukio, Yashiro, Masakazu, Ogawa, Yoshinari, Ohira, Masaichi, Ishikawa, Tetsuro, Hirakawa-YS Chung, Kosei
Format Journal Article
LanguageEnglish
Published Greece 01.05.2002
Subjects
Adult
Aged
Aged, 80 and over
Carcinoma - diagnosis
Carcinoma - metabolism
Carcinoma - mortality
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Disease-Free Survival
Female
Humans
Immunohistochemistry
Intercellular Adhesion Molecule-1 - biosynthesis
Lymphocytes, Tumor-Infiltrating - metabolism
Male
Middle Aged
Neoplasm Metastasis
Prognosis
Time Factors
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Summary:Intercellular adhesion molecule-1 (ICAM-1) is a 90-kDa cell surface glycoprotein and is known to be a member of the immunoglobulin gene superfamily of adhesion molecules. It has been suggested that ICAM-1 expression on cancer cells might have a role as a suppressor of tumor progression under the host immune surveillance system. We studied the correlation between the expression of ICAM-1 and clinicopathological factors, as well as infiltration of tumor infiltrating lymphocytes (TILs) in colorectal cancer. Resected specimens from 96 patients with colorectal carcinoma were investigated using immunohistochemical staining with a monoclonal antibody against ICAM-1. As a result, the incidence of lymph node or liver metastasis was significantly lower in patients with ICAM-1-positive tumors than in those with ICAM-1-negative tumors. Infiltration of TILs was more frequently observed in the ICAM-1-positive tumors than in the ICAM-1-negative tumors. The prognosis of the patients with ICAM-1-negative tumors was significantly poorer than that of those with ICAM-1-positive tumors. In conclusion, these findings suggested that ICAM-1 expression is closely associated with metastasis and may be a useful indicator of prognosis in patients with colorectal cancer.
ISSN:1021-335X
DOI:10.3892/or.9.3.511