Immune response to tetravalent meningococcal vaccine: opsonic and bactericidal functions of normal and properdin deficient sera

Neisseria meningitidis serogroup W-135 appears to be a fairly common cause of infection associated with properdin deficiency or dysfunction, and anticapsular antibodies might be protective in these patients. For this reason, bactericidal and opsonophagocytic activities for serogroup W-135 were inves...

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Published inEuropean journal of clinical microbiology & infectious diseases Vol. 8; no. 3; p. 220
Main Authors Söderström, C, Braconier, J H, Käyhty, H, Sjöholm, A G, Thuresson, B
Format Journal Article
LanguageEnglish
Published Germany 01.03.1989
Subjects
Adult
Antibodies, Bacterial - biosynthesis
Bacterial Vaccines - immunology
Complement Activation
Complement Pathway, Alternative
Complement Pathway, Classical
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin A - biosynthesis
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Immunoglobulins - analysis
Male
Meningococcal Vaccines
Neisseria meningitidis - immunology
Opsonin Proteins - immunology
Phagocytosis
Properdin - deficiency
Vaccination
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Summary:Neisseria meningitidis serogroup W-135 appears to be a fairly common cause of infection associated with properdin deficiency or dysfunction, and anticapsular antibodies might be protective in these patients. For this reason, bactericidal and opsonophagocytic activities for serogroup W-135 were investigated before and four weeks after vaccination of two properdin-deficient adults with tetravalent meningococcal vaccine. In addition, the response of IgM, IgG and IgA class antibodies to the serogroups A, C, Y and W-135 was determined by ELISA. There was no evidence of poor antibody responses in the properdin-deficient persons. Vaccination promoted classical pathway-mediated killing in serum and opsonization of serogroup W-135 to the same extent as that seen in vaccinated controls. The increase of alternative pathway-mediated killing in the properdin-deficient sera was moderate, but vaccination clearly enhanced alternative pathway-mediated opsonophagocytosis in the sera. It was also shown that vaccination markedly reduced the requirement for properdin in alternative pathway-mediated killing of the meningococci.
ISSN:0934-9723
DOI:10.1007/BF01965264