The role of repair in radiobiology

Apart from cancer and mutation induction, radiobiological effects on mammals are mostly attributable to cell 'death', defined as loss of proliferative capacity. Survival curves relate retention of that capacity to radiation dose, and often manifest a quasi-threshold ('shoulder')....

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Bibliographic Details
Published inExperientia Vol. 45; no. 1; p. 21
Main Authors Alper, T, Cramp, W A
Format Journal Article
LanguageEnglish
Published Switzerland 15.01.1989
Subjects
Animals
Cell Survival - radiation effects
DNA - radiation effects
DNA Damage - radiation effects
DNA Repair
Dose-Response Relationship, Radiation
Humans
Mathematics
Radiation Tolerance
Radiation, Ionizing
Radiobiology
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Summary:Apart from cancer and mutation induction, radiobiological effects on mammals are mostly attributable to cell 'death', defined as loss of proliferative capacity. Survival curves relate retention of that capacity to radiation dose, and often manifest a quasi-threshold ('shoulder'). The shoulder is attributable to an initial mechanism of repair ('Q-repair') which is gradually depleted as dose increases. Another form of repair, which is not depleted ('P-repair'), increases the dose required to deliver an average of one lethal event per cell (dose 'D0'). Neither form of repair can unambiguously be linked with repair of defects in isolated DNA. An important initial lesion may well be disruption of the complex structural relationship between the DNA, nuclear membrane and associated proteins. One form of P-repair may be restoration of that structural relationship.
ISSN:0014-4754
DOI:10.1007/BF01990449