New approach of using medicinal mushrooms for managing and curing multiple sclerosis

• Published in: Fitoterapia Vol. 185; p. 106684
• Main Authors: Pourmohammadi, Golchehr, Moghimi, Hamid
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025
• Subjects: Agaricales - chemistry; Animals; Herbal remedies; Humans; Medicines side effects; Multiple Sclerosis - drug therapy; Mushrooms; Phytotherapy; Polysaccharide; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Terpenes; RRMS; Medicines side effects; BBB; PPMS; Mushrooms; SPMS; MS; EAE; CNS; CHM; PAF; Terpenes; BRM; NDs; Herbal remedies; Polysaccharide
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2025.106684

Multiple Sclerosis (MS) is a worldwide condition related to the central nervous system (CNS). This disease affects women more than men. Various neurological symptoms characterize this disease, which can permanently disrupt the nervous system and gradually increase disability over time, weakening medical, socioeconomic and physical well-being. Currently, side effects and financial issues have largely limited the use of chemical drugs to cure MS. Another promising option for curing MS is the use of herbal remedies, especially medicinal mushrooms. Numerous studies suggest that medicinal mushrooms are helpful in the treatment of MS due to their active compounds, particularly polysaccharides, terpenes and peptides. Key factors that may be responsible for the therapeutic benefits of these mushrooms in MS treatment include increased production of antioxidant enzymes, improved function of organs such as the liver and gut, increased immune system performance, increased B and T cells, anti-inflammatory effects and nerve cell protection. In this review article, we assess the latest advances in MS treatment, address the side effects of chemical medications for this disease, and examine the potential benefits of using herbs and medicinal mushrooms. In addition, we have analyzed the mechanisms by which their active ingredients might help in the treatment of MS. It is worth mentioning that medicinal mushrooms could play an important role in the treatment of MS in the near future. [Display omitted] •Has not been published before.•Is not presently being considered for publication elsewhere.•Does not violate any intellectual property right of any person or entity.•Does not contain any subject matter that contravenes any laws.