Newly detected diabetes mellitus patients with acute coronary syndrome have an adverse cardiometabolic profile similar to patients with prior diabetes and a more extensive ischemic myocardial insult

• Published in: Diabetes research and clinical practice Vol. 211; p. 111664
• Main Authors: Rallidis, Loukianos S, Papathanasiou, Konstantinos A, Tsamoulis, Donatos, Bouratzis, Vasileios, Leventis, Ioannis, Kalantzis, Charalampos, Malkots, Belkis, Kalogeras, Petros, Tasoulas, Dimitrios, Delakis, Iosif, Lykoudis, Anastasios, Daios, Stylianos, Potoupni, Victoria, Zervakis, Stelios, Theofilatos, Athinagoras, Kotrotsios, Georgios, Kostakou, Peggy M, Kostopoulos, Konstantinos, Gounopoulos, Pantelis, Mplani, Virginia, Zacharis, Evangelos, Barmpatzas, Nikolaos, Kotsakis, Athanasios, Papadopoulos, Christodoulos, Trikas, Athanasios, Ziakas, Antonios, Skoularigis, Ioannis, Naka, Katerina K, Tziakas, Dimitrios, Panagiotakos, Demosthenes, Vlachopoulos, Charalambos
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.05.2024
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - complications; Acute Coronary Syndrome - epidemiology; Aged; Blood Glucose - analysis; Blood Glucose - metabolism; Body mass index; Diabetes Mellitus - epidemiology; Female; Glycated Hemoglobin - analysis; Glycated Hemoglobin - metabolism; Greece - epidemiology; Humans; Male; Middle Aged; Multivessel coronary artery disease; Myocardial insult; Myocardial Ischemia - blood; Myocardial Ischemia - epidemiology; Newly detected diabetes mellitus; Prevalence; Prospective Studies; Registries; Waist circumference; Greece; Multivessel coronary artery disease; Body mass index; Waist circumference; Myocardial insult; Newly detected diabetes mellitus; Acute coronary syndrome
• ISSN: 0168-8227; 1872-8227; 1872-8227
• DOI: 10.1016/j.diabres.2024.111664

[Display omitted] •The prevalence of newly detected DM (NDDM) among ACS patients was ∼ 7 %•NDDM patients develop atherogenic dyslipidemia similar to patients with prior diabetes.•NDDM patients have a central obesity phenotype comparable to patients with prior diabetes.•NDDM patients suffering ACS have more severe myocardial insult than patients with prior diabetes. The impact of newly detected diabetes mellitus (NDDM) on metabolic parameters and extent of myocardial necrosis in patients with acute coronary syndrome (ACS) is not fully explored. We examined the impact of NDDM on cardiometabolic characteristics and myocardial necrosis in ACS patients. CALLINICUS-Hellas Registry is an ongoing prospective multicenter observational study evaluating the adherence to lipid-lowering therapy (LLT) among ACS patients in Greece. Three groups were created: a) patients with NDDM (abnormal fasting glucose, HbA1c ≥ 6.5 % and no previous history of DM), b) patients without known DM and HbA1c < 6.5 % (non-DM) and c) patients with prior DM. The prevalence of NDDM among 1084 patients was 6.9 %. NDDM patients had lower HDL-C [38 (32–45) vs 42 (36–50) mg/dL] and higher triglycerides levels [144 (104–231) vs 115 (87–152) mg/dL] compared to non-DM patients (p < 0.05). NDDM patients featured both higher body mass index [29.5 (26.4–34.3) vs 27.1 (24.9–29.9) kg/m2] and waist circumference [107 (100–114) vs 98 (91–106) cm] compared to non-DM patients (p < 0.05). In addition, NDDM patients had more extensive myocardial necrosis than patients with prior DM. ACS patients with NDDM have an adverse cardiometabolic profile similar to patients with prior DM and have more extensive myocardial insult.