Zinc hybrid polyester barrier membrane accelerates guided tissue regeneration

• Published in: Journal of controlled release Vol. 368; pp. 676 - 690
• Main Authors: Zhang, Qiao, Lou, Chaoqian, Li, Hang, Li, Yanyan, Zhang, Hongjie, Li, Zimeng, Qi, Ganggang, Cai, Xia, Luo, Qiaojie, Fan, Lijie, Li, Xiaojun, Lao, Weiwei, Zhu, Weipu, Li, Xiaodong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2024
• Subjects: Aliphatic polyester; Antibacterial activity; Bioactive guided tissue regeneration; Space maintaining; Zinc catalyzation; Space maintaining; Zinc catalyzation; Antibacterial activity; Aliphatic polyester; Bioactive guided tissue regeneration
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2024.03.005

Barrier membranes play a pivotal role in the success of guided periodontal tissue regeneration. The biodegradable barriers predominantly used in clinical practice often lack sufficient barrier strength, antibacterial properties, and bioactivity, frequently leading to suboptimal regeneration outcomes. Although with advantages in mechanical strength, biodegradability and plasticity, bioinert aliphatic polyesters as barrier materials are usually polymerized via toxic catalysts, hard to be functionalized and lack of antibacterial properties. To address these challenges, we propose a new concept that controlled release of bioactive substance on the whole degradation course can give a bioinert aliphatic polyester bioactivity. Thus, a Zn-based catalytic system for polycondensation of dicarboxylic acids and diols is created to prepare zinc covalent hybrid polyester (PBS/ZnO). The atomically-dispersed Zn2+ ions entering main chain of polyester molecules endow PBS/ZnO barrier with antibacterial properties, barrier strength, excellent biocompatibility and histocompatibility. Further studies reveal that relying on long-term controlled release of Zn2+ ions, the PBS/ZnO membrane greatly expedites osteogenetic effect in guided tissue regeneration (GTR) by enhancing the mitochondrial function of macrophages to induce M2 polarization. These findings show a novel preparation strategy of bioactive polyester biomaterials based on long term controlled release of bioactive substance that integrates catalysis, material structures and function customization. By using a newly designed zinc compound catalyst, a Zn2+-containing aliphatic polyester was successfully prepared. The resultant polyester not only has antibacterial property and mechanical properties, but also enhances osteogenetic effects through improving the mitochondrial function of macrophages when used as a GTR membrane. [Display omitted] •Zinc based catalyst is used to prepare poly(butylene succinate) (PBS/ZnO).•PBS/ZnO barrier shows good antibacterial property and osteogenetic effect in GTR.•PBS/ZnO enhances macrophage mitochondrial function to induce M2 polarization.•Bioacitve PBS/ZnO polyester shows a broad application prospect in biomedical field.