DNA polymorphism of the major histocompatibility class I genes and their association with serologically defined haplotypes

DNA of unrelated persons as well as members of families that were totally or partially homozygous or completely heterozygous on the loci of the major histocompatibility class I genes has been isolated from peripheral blood lymphocytes and blot hybridized with the class I pseudogene pHLA 12.4 probe....

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Bibliographic Details
Published inImmunogenetics (New York) Vol. 21; no. 6; p. 529
Main Authors Driesel, A J, Römer, K, Schunter, F, Laryea, M D, Schneider, E M, Wernet, P, Henke, J, Basler, M, Kömpf, J
Format Journal Article
LanguageEnglish
Published United States 01.01.1985
Subjects
Alleles
DNA - isolation & purification
DNA Restriction Enzymes
Genes, MHC Class II
Genetic Linkage
Heterozygote
Homozygote
Humans
Lymphocytes - immunology
Major Histocompatibility Complex
Nucleic Acid Hybridization
Polymorphism, Genetic
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Summary:DNA of unrelated persons as well as members of families that were totally or partially homozygous or completely heterozygous on the loci of the major histocompatibility class I genes has been isolated from peripheral blood lymphocytes and blot hybridized with the class I pseudogene pHLA 12.4 probe. The autoradiographic DNA patterns were discussed and compared with well-defined serological features. Positive associations with serologically typed alleles had been demonstrated for HLA-A1,11; -A2; -A3; -B7; -B14; -B35; -Bw41; and -Cw5.
ISSN:0093-7711
DOI:10.1007/BF00395877