Increased incidence of unilateral sudden sensorineural hearing loss in patients with hematological malignancies requiring hematopoietic stem cell transplantation

Haematopoietic stem cell transplantation (HSCT) may dramatically alter the immunity of a recipient. Transient immunodeficiency that occurs before and after HSCT could be associated with the development of sudden sensorineural hearing loss (SSNHL), which is presumed to be often due to viral aetiology...

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Bibliographic Details
Published inClinical otolaryngology Vol. 46; no. 6; pp. 1278 - 1281
Main Authors Bae, Seong Hoon, Lee, Yujin, Jung, Jinsei
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.11.2021
Subjects
Adult
Blood cancer
Cohort Studies
Female
Hearing
Hearing loss
Hearing Loss, Sensorineural - immunology
Hearing Loss, Sudden - immunology
Hematologic Neoplasms - therapy
hematological neoplasm
Hematology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Immunocompromised Host
Immunodeficiency
Incidence
Male
Malignancy
Middle Aged
Patients
Retrospective Studies
Stem cell transplantation
Stem cells
sudden sensorineural hearing loss
Transplantation
hematopoietic stem cell transplantation
incidence
hematological neoplasm
sudden sensorineural hearing loss
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Summary:Haematopoietic stem cell transplantation (HSCT) may dramatically alter the immunity of a recipient. Transient immunodeficiency that occurs before and after HSCT could be associated with the development of sudden sensorineural hearing loss (SSNHL), which is presumed to be often due to viral aetiology. We found an incidence of SSNHL of 29.4 per 10,000 person‐years in patients receiving HSCT, 12‐fold higher than reported for background population incidence. Development of SSNHL tended to cluster early after diagnosis of haematological malignancies, rather than around date of treatment with HSCT. Increased risk of unilateral SSNHL in patients with haematological malignancy may relate to underlying disease rather than treatment
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1749-4478
1749-4486
DOI:10.1111/coa.13829