Coxiella burnetii serostatus in dromedary camels (Camelus dromedarius) is associated with the presence of C. burnetii DNA in attached ticks in Laikipia County, Kenya

• Published in: Zoonoses and public health Vol. 71; no. 5; pp. 503 - 514
• Main Authors: Rooney, Tess, Fèvre, Eric M., Villinger, Jandouwe, Brenn‐White, Maris, Cummings, Charles O., Chai, Daniel, Kamau, Joseph, Kiyong'a, Alice, Getange, Dennis, Ochieng, Dickens O., Kivali, Velma, Zimmerman, Dawn, Rosenbaum, Marieke, Nutter, Felicia B., Deem, Sharon L.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.08.2024
• Subjects: Arid environments; arthropod; camelid; Camelidae; Camelids; Camels; Camelus dromedarius; Coxiella; Coxiella burnetii; Demographic variables; Demographics; Demography; Disease transmission; Endosymbionts; Environmental health; Epidemiology; Infections; Livestock; Nucleotide sequence; One Health; Parasitic diseases; Pathology; Polymerase chain reaction; Public health; Q fever; Regression analysis; Reproductive health; Reproductive pathology; Serology; Ticks; Wildlife; Year class; Zoonoses; Kenya; zoonoses; arthropod; Q fever; livestock; One Health; camelid
• ISSN: 1863-1959; 1863-2378; 1863-2378
• DOI: 10.1111/zph.13127

Aims Q fever is a globally distributed, neglected zoonotic disease of conservation and public health importance, caused by the bacterium Coxiella burnetii. Coxiella burnetii normally causes subclinical infections in livestock, but may also cause reproductive pathology and spontaneous abortions in artiodactyl species. One such artiodactyl, the dromedary camel (Camelus dromedarius), is an increasingly important livestock species in semi‐arid landscapes. Ticks are naturally infected with C. burnetii worldwide and are frequently found on camels in Kenya. In this study, we assessed the relationship between dromedary camels' C. burnetii serostatus and whether the camels were carrying C. burnetii PCR‐positive ticks in Kenya. We hypothesized that there would be a positive association between camel seropositivity and carrying C. burnetii PCR‐positive ticks. Methods and Results Blood was collected from camels (N = 233) from three herds, and serum was analysed using commercial ELISA antibody test kits. Ticks were collected (N = 4354), divided into pools of the same species from the same camel (N = 397) and tested for C. burnetii and Coxiella‐like endosymbionts. Descriptive statistics were used to summarize seroprevalence by camel demographic and clinical variables. Univariate logistic regression analyses were used to assess relationships between serostatus (outcome) and tick PCR status, camel demographic variables, and camel clinical variables (predictors). Camel C. burnetii seroprevalence was 52%. Across tick pools, the prevalence of C. burnetii was 15% and Coxiella‐like endosymbionts was 27%. Camel seropositivity was significantly associated with the presence of a C. burnetii PCR‐positive tick pool (OR: 2.58; 95% CI: 1.4–5.1; p = 0.0045), increasing age class, and increasing total solids. Conclusions The role of ticks and camels in the epidemiology of Q fever warrants further research to better understand this zoonotic disease that has potential to cause illness and reproductive losses in humans, livestock, and wildlife.