Brain‐derived neurotrophic factor in degenerative retinal diseases: Update and novel perspective

Dysfunction and death of neuronal cells are cardinal features of degenerative retinal diseases that are known to arise as the disease progresses. Increasingly evidence suggests that abnormal expression of brain‐derived neurotrophic factor (BDNF) may serve as an obligatory relay of the dysfunction an...

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Bibliographic Details
Published inJournal of neuroscience research Vol. 101; no. 10; pp. 1624 - 1632
Main Authors Zhang, Qing‐Qing, Qu, Yi
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.10.2023
Subjects
Apoptosis
Brain
Brain-Derived Neurotrophic Factor
Cell death
Degenerative diseases
degenerative retinal diseases
Humans
Inflammation
neurodegeneration
neurogenesis
neuroinflammation
neuroprotection
Retina
Retinal degeneration
Retinal Diseases
neurodegeneration
neurogenesis
brain-derived neurotrophic factor
neuroinflammation
neuroprotection
degenerative retinal diseases
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Summary:Dysfunction and death of neuronal cells are cardinal features of degenerative retinal diseases that are known to arise as the disease progresses. Increasingly evidence suggests that abnormal expression of brain‐derived neurotrophic factor (BDNF) may serve as an obligatory relay of the dysfunction and death of neuronal cells in degenerative retinal diseases. Although disorder of BDNF, whether depletion or augmentation, has been connected with neuronal apoptosis and neuroinflammation, the exact mechanisms underlying the effect of impaired BDNF expression on degenerative retinal diseases remain unclear. Here, we present an overview of how BDNF is linked to pathological mechanism of retinal degenerative diseases, summarize BDNF‐based treatment strategies, and discuss possible research perspectives in the future.
Bibliography:Edited by Junie Paula Warrington and Royce Mohan. Reviewed by Carla Lucini.
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ISSN:0360-4012
1097-4547
1097-4547
DOI:10.1002/jnr.25226