The role of the genetic influence of DRD4 in Chinese adults in the context of the choice of tourist attractions

• Published in: The European journal of neuroscience Vol. 59; no. 8; pp. 2016 - 2028
• Main Authors: Chen, Ze Geng, Fu, Shi Min
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.04.2024
• Subjects: addiction; Adult; behaviour; Decision making; dopamine D4 receptor; Dopamine D4 receptors; Emotions; Exons; Female; Genetic variability; Genomes; Genotype; Genotypes; Genotyping; Humans; Influence; Male; Minisatellite Repeats; polymorphism; Receptors, Dopamine D4 - genetics; Tourist attractions; behaviour; polymorphism; decision‐making; emotions; addiction; dopamine D4 receptor
• ISSN: 0953-816X; 1460-9568; 1460-9568
• DOI: 10.1111/ejn.16283

The aim of this work was to analyse the effect of tandem repetitions in exon III of the DRD4 gene on the features of human decision‐making in a model of choosing tourist attractions by adult residents of China. The study included 380 subjects: 162 (42.6%) men and 218 (57.4%) women. The mean age of the subjects was 31.7 ± 3.32 years. As a result of the survey of subjects, 5 groups of motivations for choosing tourist attractions were identified, and the frequency of their use, including the identified combinations, was determined. Using the genotyping method, the frequency of DRD4 subtypes among the subjects was determined, and their relationship with the indicated attraction selection groups was studied. It has been established that there is a significant dependence of the frequency of choosing the attractors ‘relaxation’, ‘desire for novelty’ and ‘self‐realization’ and their combinations on the frequency of occurrence of the DRD4 2R, 4R and 5R+ subtypes in the study groups. A conclusion was made about the possible mechanism of the influence of manifestations of DRD4 subtypes on the choice of tourist attractors by implementing the neurophysiological influence of the genome on reducing the sensitivity of brain receptors to dopamine, which stimulates behaviours that compensate for the need for additional emotional influences. This work complements the existing knowledge about the impact of human innate properties on the characteristics of his behaviour and possible patterns of influence of human genotype variability on decision‐making and suggests further possible directions of research in this area. Analysing the effect of tandem repeats in exon III of the DRD4 gene on human decision‐making features in a model of tourist attraction selection by Chinese adults.