Virus-associated haemophagocytic syndrome: further evidence for a T-cell mediated disorder

A 16-year-old youth with life-threatening virus-associated haemophagocytic syndrome (VAHS) responded remarkably to treatment with cyclosporin A during two periods of active disease, the second of which was due to noncompliance with treatment. Our clinical observations support the hypothesis that VAH...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of haematology Vol. 86; no. 1; p. 213
Main Authors Watson, H G, Goulden, N J, Manson, L M, McDermid, G, Gray, J A, Parker, A C
Format Journal Article
LanguageEnglish
Published England 01.01.1994
Subjects
Adolescent
Cyclosporine - therapeutic use
Histiocytosis, Non-Langerhans-Cell - blood
Histiocytosis, Non-Langerhans-Cell - drug therapy
Histiocytosis, Non-Langerhans-Cell - immunology
Humans
Male
Platelet Count
T-Lymphocytes - immunology
Virus Diseases - immunology
Online AccessGet more information

Cover

More Information
Summary:A 16-year-old youth with life-threatening virus-associated haemophagocytic syndrome (VAHS) responded remarkably to treatment with cyclosporin A during two periods of active disease, the second of which was due to noncompliance with treatment. Our clinical observations support the hypothesis that VAHS is cytokine driven as a result of an aberrant T-cell response to infection.
ISSN:0007-1048
DOI:10.1111/j.1365-2141.1994.tb03282.x