Association between periodontal disease and malignant soft tissue sarcomas

• Published in: Oral diseases Vol. 30; no. 7; pp. 4731 - 4739
• Main Authors: Hiroshimaya, Takatoshi, Fujimoto, Yusuke, Sasaki, Hiromi, Motoi, Toshihiro, Nagata, Emi, Taniguchi, Noboru, Oho, Takahiko
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2024
• Subjects: Aged; Bone surgery; Female; Gastrointestinal tract; Gum disease; Humans; Inflammation; Lung diseases; Male; malignant soft tissue sarcoma; Middle Aged; Oral cavity; Orthopedics; Patients; periodontal disease; Periodontal diseases; Periodontal Diseases - complications; periodontal inflamed surface area; Periodontitis; Periodontitis - complications; Propensity Score; Retrospective Studies; Sarcoma - complications; Soft Tissue Neoplasms - complications; Soft tissue sarcoma; Surgery; malignant soft tissue sarcoma; periodontal inflamed surface area; periodontal disease; propensity score
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14853

Objective Malignant soft tissue sarcoma (MSTS) is a rare disease, but is seen in patients undergoing orthopedic surgery. Although the association of periodontal disease with various cancers occurring in the oral cavity, gastrointestinal tract, lungs, and prostate, has been reported, the association between periodontal disease and MSTS remains unclear. This study investigated the association between periodontal disease and MSTS in patients undergoing orthopedic surgery. Subjects and Methods One hundred fifteen patients who underwent orthopedic surgery between 2017 and 2021 were retrospectively enrolled (mean age = 66.8 ± 10.7 years). The patient background was adjusted by the propensity score (PS). Subsequently, the association of periodontal disease with MSTS was analyzed using PS inverse probability of treatment weighting (IPTW). Periodontal status was determined by evaluating the periodontal inflamed surface area, which was calculated by measuring the periodontal probing pocket depth and detecting bleeding on probing. Results Multivariate logistic regression analysis after adjustment by the PS showed that severe periodontitis was significantly associated with MSTS (odds ratio 2.81, p = 0.04). Furthermore, IPTW showed that severe periodontitis was significantly associated with MSTS (odds ratio 3.21, p = 0.01). Conclusion The results indicate an association between periodontal inflammation and MSTS.