Antrodia cinnamomea prevents ovariectomized‐promoted bone loss by inhibiting osteoclast formation

Osteoporosis is a common bone disease in aging populations, particularly in postmenopausal women. Anti‐resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are linked with a variety of adverse effects. Antrodia cinnamomea extracts (ACE) are highly renowned for their a...

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Published inEnvironmental toxicology Vol. 39; no. 6; pp. 3381 - 3388
Main Authors Po‐Chun, Chang, Su, Hui‐Kan, Liu, Shan‐Chi, Thuong, Le Huynh Hoai, Wu, Yang‐Chang, Chen, Hsien‐Te, Wu, Tung‐Ying, Tang, Chih‐Hsin
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.06.2024
Wiley Subscription Services, Inc
Subjects
Anabolism
Animal models
Animals
Antrodia cinnamomea
Biomechanics
Bone diseases
Bone loss
Bone Resorption - drug therapy
Bone Resorption - prevention & control
Bones
Female
Inflammation
Mechanical properties
Mice
osteoclast
Osteoclasts - drug effects
Osteoporosis
Osteoporosis - drug therapy
Osteoporosis - pathology
Osteoporosis - prevention & control
ovariectomized
Ovariectomy
Polyporales - chemistry
Post-menopause
RANK Ligand
Rats
Rats, Sprague-Dawley
RAW 264.7 Cells
ovariectomized
osteoclast
osteoporosis
Antrodia cinnamomea
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Summary:Osteoporosis is a common bone disease in aging populations, particularly in postmenopausal women. Anti‐resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are linked with a variety of adverse effects. Antrodia cinnamomea extracts (ACE) are highly renowned for their anticancer, antioxidative, and anti‐inflammatory properties. However, whether ACE‐enriched anti‐osteoporosis functions are largely unknown. In a preclinical animal model, we found that ovariectomy significantly decreased bone volume in the ovariectomized (OVX) rats. Administration of ACE antagonized OVX‐induced bone loss. In addition, ACE reversed OVX‐reduced biomechanical properties. The serum osteoclast marker also showed improvement in the ACE‐treated group. In the cellular model, it was indicated that ACE inhibits RANKL‐induced osteoclast formation. Taken together, ACE seems to be a hopeful candidate for the development of novel anti‐osteoporosis treatment.
Bibliography:Po‐Chun, Chang and Hui‐Kan Su contributed equally to this study.
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ISSN:1520-4081
1522-7278
DOI:10.1002/tox.24212