Laryngeal paraganglioma: The analysis of misdiagnosed cases and literature review

• Published in: Head & neck Vol. 46; no. 5; pp. 1234 - 1247
• Main Authors: Dong, Yi‐Jun, Zhang, Hong‐Hui, Liang, Jia‐Qiao, Gao, Ya‐Ya, Xiong, Ming, Yang, Hui
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2024; Wiley Subscription Services, Inc
• Subjects: Laryngeal carcinoma; larynx; Literature reviews; misdiagnosis; neuroendocrine neoplasm; Neuroendocrine tumors; Paraganglioma; thyroid; larynx; thyroid; misdiagnosis; neuroendocrine neoplasm; paraganglioma
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.27762

Laryngeal paraganglioma (LP) is an exceptionally rare neuroendocrine tumor, underscoring importance of accurate identification to preclude misdiagnoses. In this review, we presented two typical misdiagnosed LPs, and offered reviews of LP cases reported over the preceding decade and all documented misdiagnosed LP cases. Furthermore, we systematically investigated the underlying causes of misdiagnosis and elucidated key points for effective differentiation. A retrospective analysis of 28 LP cases revealed a predominant occurrence in middle‐aged women, with an average history of 25.1 months. Through an analysis of all misdiagnosed cases (n = 37), supraglottic LPs were frequently misidentified as laryngeal carcinomas and vascular tumors, while subglottic LPs were often misdiagnosed as thyroid cancers. And the occurrence of misdiagnosis resulted in delayed and inappropriate treatments, contributing to the deterioration of LP patients (14 cases, 37.8%). In conclusion, this review endeavored to heighten awareness of LPs, with the ultimate goal of advancing diagnostic precision and enhancing patient outcomes.