LncRNA in periodontal tissue‐derived cells on osteogenic differentiation in the periodontitis field

• Published in: Oral diseases Vol. 30; no. 7; pp. 4087 - 4097
• Main Authors: Du, Yuanhang, Guan, Xiaoyan, Zhu, Yinci, Jin, Suhan, Liu, Jianguo
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2024
• Subjects: Cell differentiation; Cell Differentiation - genetics; Epigenesis, Genetic; Epigenetics; Gum disease; Humans; lncRNAs; mechanism; Non-coding RNA; Osteogenesis - genetics; osteogenic differentiation; periodontal tissue‐derived cells; Periodontitis; Periodontitis - genetics; Periodontium - cytology; RNA, Long Noncoding - genetics; lncRNAs; mechanism; osteogenic differentiation; periodontal tissue‐derived cells; periodontitis
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14970

Objective Periodontitis can lead to the destruction of periodontal tissues and potentially tooth loss. Numerous periodontal tissue‐derived cells display osteogenic differentiation potential. The presence of differentially expressed long non‐coding RNAs (lncRNAs) in these cells indicate their ability to regulate the process of osteogenic differentiation. We aim to elucidate the various lncRNA‐mediated regulatory mechanisms in the osteogenic differentiation of periodontal tissue‐derived cells in the field of periodontitis at epigenetic modification, transcriptional, and post‐transcriptional levels. Subjects and Methods We systematically searched the PubMed, Web of Science, and ScienceDirect databases to identify relevant literature in the field of periodontitis discussing the role of lncRNAs in regulating osteogenic differentiation of periodontal tissue‐derived cells. The identified literature was subsequently summarized for comprehensive review. Results In this review, we have comprehensively summarized the regulatory mechanisms of lncRNAs in the osteogenic differentiation of periodontal tissue‐derived cells in the field of periodontitis and discussed how these lncRNAs provide novel perspectives for understanding the pathogenesis and progression of periodontitis. Conclusion These results indicate the pivotal role of lncRNAs as regulators in the osteogenic differentiation of periodontal tissue‐derived cells, providing a solid basis for future investigations on the role of lncRNAs in the periodontitis field.