Implications of environmental nanoparticles on neurodegeneration

The ubiquity of nanoparticles, sourced from both natural environments and human activities, presents critical challenges for public health. While offering significant potential for innovative biomedical applications—especially in enhancing drug transport across the blood–brain barrier—these particle...

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Published inJournal of neuroscience research Vol. 102; no. 5; pp. e25340 - n/a
Main Authors Hermosillo‐Abundis, Cristina, Méndez‐Rojas, Miguel A., Arias‐Carrión, Oscar
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.05.2024
Subjects
Animals
Biomedical materials
Blood-brain barrier
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - metabolism
Brain - drug effects
Brain - metabolism
Environmental Exposure - adverse effects
environmental health
Environmental impact
Health risks
Humans
Medical innovations
Nanoparticles
Nanoparticles - toxicity
nanotoxicology
Natural environment
Neurodegeneration
Neurodegenerative Diseases
Neurotoxicity
Public health
neurodegeneration
blood–brain barrier
nanoparticles
environmental health
nanotoxicology
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Summary:The ubiquity of nanoparticles, sourced from both natural environments and human activities, presents critical challenges for public health. While offering significant potential for innovative biomedical applications—especially in enhancing drug transport across the blood–brain barrier—these particles also introduce possible hazards due to inadvertent exposure. This concise review explores the paradoxical nature of nanoparticles, emphasizing their promising applications in healthcare juxtaposed with their potential neurotoxic consequences. Through a detailed examination, we delineate the pathways through which nanoparticles can reach the brain and the subsequent health implications. There is growing evidence of a disturbing association between nanoparticle exposure and the onset of neurodegenerative conditions, highlighting the imperative for comprehensive research and strategic interventions. Gaining a deep understanding of these mechanisms and enacting protective policies are crucial steps toward reducing the health threats of nanoparticles, thereby maximizing their therapeutic advantages.
Bibliography:Stephen Crocker, Associate Editor, Journal of Neuroscience Research.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.25340