Renal tubular dysfunction caused by dietary hexachlorocyclohexane (HCH) isomers

Dietary administration of beta- and gamma-hexachlorocyclohexane (HCH) to albino rats caused an abnormal excessive excretion of glucose in the urine, blood glucose level being nearly normal. Occurrence of glucosuria was also accompanied by increased excretions of the two low-threshold compounds - cre...

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Bibliographic Details
Published inJournal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes Vol. 19; no. 4-5; p. 453
Main Authors Srinivasan, K, Ramesh, H P, Radhakrishnamurty, R
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
Animals
Creatinine - urine
Diet
Isomerism
Kidney Diseases - chemically induced
Kidney Tubules - drug effects
Kidney Tubules - pathology
Lindane - toxicity
Lipid Metabolism
Male
Organ Size - drug effects
Proteins - metabolism
Rats
Rats, Inbred Strains
Urea - urine
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Summary:Dietary administration of beta- and gamma-hexachlorocyclohexane (HCH) to albino rats caused an abnormal excessive excretion of glucose in the urine, blood glucose level being nearly normal. Occurrence of glucosuria was also accompanied by increased excretions of the two low-threshold compounds - creatinine and urea, their levels in blood being normal. The interference of HCH isomers with renal function as evidenced by biochemical data was also indicated by histopathological lesions observed in the kidney sections, viz., hypertrophy and degeneration of the renal tubular epithelia.
ISSN:0360-1234
DOI:10.1080/03601238409372443