Renal tubular dysfunction caused by dietary hexachlorocyclohexane (HCH) isomers
Dietary administration of beta- and gamma-hexachlorocyclohexane (HCH) to albino rats caused an abnormal excessive excretion of glucose in the urine, blood glucose level being nearly normal. Occurrence of glucosuria was also accompanied by increased excretions of the two low-threshold compounds - cre...
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Published in | Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes Vol. 19; no. 4-5; p. 453 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
01.01.1984
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Subjects | |
Online Access | Get more information |
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Summary: | Dietary administration of beta- and gamma-hexachlorocyclohexane (HCH) to albino rats caused an abnormal excessive excretion of glucose in the urine, blood glucose level being nearly normal. Occurrence of glucosuria was also accompanied by increased excretions of the two low-threshold compounds - creatinine and urea, their levels in blood being normal. The interference of HCH isomers with renal function as evidenced by biochemical data was also indicated by histopathological lesions observed in the kidney sections, viz., hypertrophy and degeneration of the renal tubular epithelia. |
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ISSN: | 0360-1234 |
DOI: | 10.1080/03601238409372443 |