Role of Nicotinic and Muscarinic Cholinoreceptors in the Realization of the Cholinergic Anti-Infl ammatory Pathway during the Early Phase of Sepsis

• Published in: Bulletin of experimental biology and medicine Vol. 153; no. 5; pp. 700 - 703
• Main Authors: Zabrodskii, P. F., Lim, V. G., Shekhter, M. S., Kuzmin, A. V.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2012; Springer Nature B.V
• Subjects: Acetylcholine receptors (muscarinic); Acetylcholine receptors (nicotinic); Biomedical and Life Sciences; Biomedicine; Blood; Cell Biology; Interleukin 1; Interleukin 6; Internal Medicine; Laboratory Medicine; Leukocytes (neutrophilic); Monocytes; Mortality; Nicotine; Pathology; Phagocytes; Sepsis; cytokines; cholinergic anti-infl ammatory pathway; phagocytic monocytic system; nicotinic and muscarinic cholinoreceptors; sepsis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1803-8

Stimulation of nicotinic and muscarinic cholinoreceptors (nAChR, mAChR) in outbred albino mice with nicotine and aceclidine, respectively, in single equilethal doses 0.5 DL 50 6 h before sepsis induction signifi cantly reduced animal mortality due to a decrease in blood concentrations of proinfl ammatory cytokines IL-1β, IL-6, and MIP-2. Stimulation of mAChR (injection of aceclidine) stimulated the neutrophilic phagocytic and metabolic activity. Realization of the cholinergic anti-infl ammatory pathway (stimulation of the peripheral nicotinic cholinoreceptors (α7nAChR) and central muscarinic cholinoreceptors (mAChR) was modulated by stimulation of the muscarinic cholinoreceptors of the phagocytic monocytic system cells.