The synthesis of perfluoroalkylated indolizines via tandem cyclization/aromatization

•Described herein is a convenient protocol for the synthesis of perfluoroalkylated indolizines.•A tandem cyclization/aromatization process was developed for the synthesis.•Perfluoroalkylated indolizines were formed by the construction of the pyridine rings. The incorporation of a perfluoroalkyl grou...

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Bibliographic Details
Published inJournal of fluorine chemistry Vol. 251; pp. 109900 - 109906
Main Authors Wang, Xiaoli, Sun, Xiaoli, Li, Na, Chen, Jie, Zhang, Hui, Deng, Hongmei, Lin, Jin-Hong, Cao, Weiguo
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier B.V 01.11.2021
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Cyclization
Fluorine
Indolizines
Physical Sciences
Science & Technology
Tandem
Trifluoromethyl
Trifluoromethyl
Indolizines
Tandem
Cyclization
Fluorine
CYCLOADDITION
PALLADIUM
ONE-POT SYNTHESIS
CASCADE
ACCESS
TRIFLUOROMETHYLATION
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Summary:•Described herein is a convenient protocol for the synthesis of perfluoroalkylated indolizines.•A tandem cyclization/aromatization process was developed for the synthesis.•Perfluoroalkylated indolizines were formed by the construction of the pyridine rings. The incorporation of a perfluoroalkyl group into heterocycles has received increasing attention. Herein we describe the synthesis of perfluoroalkylated indolizines via a tandem cyclization/aromatization process under mild conditions. In contrast to previous synthetic methods, which are usually used to construct the pyrrole motif rather than the pyridine moiety in indolizines, our protocol relies on the formation of the pyridine rings. Described herein is a convenient synthesis of perfluoroalkylated indolizines via a tandem cyclization/aromatization process. [Display omitted]
ISSN:0022-1139
1873-3328
DOI:10.1016/j.jfluchem.2021.109900