Synthesis and characterization of sulfonamide metal complexes as antimicrobial agents

• Published in: Journal of molecular structure Vol. 1202; p. 127284
• Main Authors: Pervaiz, Muhammad, Riaz, Aqsa, Munir, Anfal, Saeed, Zohaib, Hussain, Shah, Rashid, Ayoub, Younas, Umar, Adnan, Ahmad
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.02.2020
• Subjects: Biological activity; Spectroscopy; Sulfa drugs; Transition metals; Spectroscopy; Transition metals; Sulfa drugs; Biological activity
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2019.127284

The sulfa drug ligands and their derivatives retain well-thought-out as pre-eminent compounds in the field of synthetic as well as pharmaceutical chemistry. The transition metal complexes of 4-amino-N-(5-methyl-3-isoxazolyl)benzene sulfonamide are synthesized by reaction of 4-amino-N-(5-methyl-3-isoxazolyl)benzene sulfonamide with metals like Mn(II), Co(II), Fe(II), Fe(III),Cr(III),Ni(II),Cu(II) and Zn(II).The synthesized metal complexes of sulfa drugs have been engaged for biological (as anti-bacterial &anti-fungal entities) as well as catalytic activity as example Olefin Polymerization. Due to broad spectrum range, the sulfa drug derived complexes are found to be very imperative in pharmaceutical and medical chemistry. Being borne in mind the worth of sulfa drug based transition metal complexes, the review has recapitulated the synthesis, characterization and antimicrobial activities of 4-amino-N-(5-methyl-3-isoxazolyl) benzene sulfonamide metal complexes. •Being borne in mind the worth of sulfa drug based transition metal complexes, the review has recapitulated the synthesis and biological activities of sulfonamide metal complexes.•Due to broad spectrum range, sulfa drug derivatives have beneficial prospective against numerous syndromes so there is a dire need for the exploration of these complexes.•In future, the project can also be boosted up to homo/hetro bimetallic metal complexes of sulfa drugs which may act as strong antimicrobial agents.