The mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants

Seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 Ames tester strains (TA92, TA94, TA97, TA98, TA100, TA102). The eight compounds are chemicals isolated from three Nigerian medicinal pla...

Full description

Saved in:
Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 13; no. 4/6; p. 521
Main Author Uwaifo, A.O
Format Journal Article
LanguageEnglish
Published United States 1984
Subjects
AFRAEGLE PANICULATA
Animals
AZADIRACHTA INDICA
CLAUSENA
CLAUSENA ANISATA
Coumarins - toxicity
DRUG PLANTS
Furans - toxicity
Lethal Dose 50
Limonins
Mutagens
NIGERIA
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - analysis
Rats
RUTACEAE
Salmonella typhimurium - drug effects
Nigeria
Online AccessGet more information

Cover

More Information
Summary:Seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 Ames tester strains (TA92, TA94, TA97, TA98, TA100, TA102). The eight compounds are chemicals isolated from three Nigerian medicinal plants: Afraegle paniculata, Clausena anisata, and Azadirachta indica. Different preparations of the former are taken by Nigerians for gut disturbances, and a concoction of the latter called "Agbo" is taken as an antimalarial. Marmesin and imperatorin were mutagenic in all tester strains except TA94 and TA102. The mutagenicity potencies of marmesin and imperatorin were 20 and 0.2 respectively. Mutagenicity was highest in TA98 and TA100 in both compounds. Marmesin was optimally mutagenic at a dose of 1.04 micrograms, and imperatorin at 30.0 micrograms. Microsomal activation was not required for mutagenicity in both compounds.
Bibliography:Q60
8617687
ISSN:0098-4108
1087-2620
DOI:10.1080/15287398409530517