Synthesis and biological activity of organosilicontitanium glycerohydrogels

• Published in: Pharmaceutical chemistry journal Vol. 43; no. 2; pp. 95 - 100
• Main Authors: Khonina, T. G, Chupakhin, O. N, Larionov, L. P, Sorokin, P. V, Zabokritskii, N. A, Suvorov, A. L, Shadrina, E. V, Ivanenko, M. V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.02.2009; Springer US
• Subjects: antioxidant activity; Medicine; Organic Chemistry; organosilicontitanium glycerohydrogels; Pharmacology/Toxicology; Pharmacy; Search for New Drugs; synthesis; wound-healing activity; synthesis; organosilicontitanium glycerohydrogels; wound-healing activity; antioxidant activity
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-009-0246-7

A series of organosilicontitanium (OST) glycerohydrogels with the general formula 2Si(C₃H₇O₃)₄ [dot operator] Ti(C₃H₇O₃)₄ [dot operator] xC₃H₈O₃ [dot operator] yH₂O (where 9 <= x <= 30 and 60 <= y <= 120) were synthesized and some of their pharmacological properties were studied. High percutaneous activity of the compounds was revealed by measuring the diffusion of sodium diclofenac through intact skin membranes in vitro. It was established that all of the synthesized substances are nontoxic. The wound-healing and antioxidant properties of the glycerohydrogels were studied. The experimental results show that OST glycerohydrogels can be recommended for further testing as effective percutaneous vehicles of medicines with wound-healing, burn-healing, and antioxidant action.