Synthesis, spectroscopic, X-ray diffraction, antimicrobial and antitumor studies of Ni(II) and Co(II) complexes derived from 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone and ethylenediamine

• Published in: Journal of molecular structure Vol. 1219; p. 128607
• Main Authors: Adly, Omima M.I., Shebl, Magdy, Abdelrhman, Ebtesam M., El-Shetary, B.A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.11.2020
• Subjects: Antimicrobial activity; Antitumor activity; Mono- and binuclear complexes; Pyridazinone; Tetradentate ligand; Mono- and binuclear complexes; Antitumor activity; Antimicrobial activity; Pyridazinone; Tetradentate ligand
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2020.128607

Reactions of the Schiff base ligand derived from 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone and ethylenediamine with Ni(II) and Co(II) using different metal salts; NO3−, AcO−, ClO4− and Cl− yielded binary metal complexes. Mixed-ligand complexes were synthesized by using extra ligands including 8-hydroxyquinoline or glycine as nitrogen, oxygen-donors; 1,10-phenanthroline or 2-aminopyridine as nitrogen, nitrogen-donors. Elemental and thermal analyses, spectroscopic techniques (IR, electronic and mass), conductivity and magnetic susceptibility measurements were utilized to characterize the structures of the complexes. Electronic spectra and magnetic moment measurements showed that all complexes are octahedral and tetrahedral. In addition, activation energies of thermal degradation were calculated by means of Coats–Redfern equations. The activation energies were also used to evaluate kinetic and thermodynamic parameter of the metal complexes including Ea, ΔH, ΔS and ΔG. The XRD patterns for the ligand and its metal complexes indicate crystalline nature with nano particle sizes. The biological activity of the chelating agent and its metal complexes was conducted towards S. aureus and B. subtilis as Gram-+ve bacteria, S. typhimurium and E. coli as Gram–-ve bacteria, C. albicans (yeast) and A. fumigatus (fungus). The chelating agent and some Ni(II) and Co(II) complexes showed antitumor activity towards HepG2 cell line. Relation between the ligand and its metal complexes and their reactivity toward Bacillus subtilis. [Display omitted] •A new nickel (II) and cobalt (II) complexes were synthesized and characterized.•The complexes exhibited octahedral and tetrahedral geometrical arrangements.•Kinetic parameters were calculated.•The XRD patterns for the ligand and its metal complexes were measured.•The metal complexes showed antimicrobial and antitumor activities.