Co-delivery of doxorubicin and quercetin by Janus hollow silica nanomotors for overcoming multidrug resistance in breast MCF-7/Adr cells

Multidrug resistance (MDR) greatly hinders the efficacy of chemotherapy in a variety of hematological malignancies and solid tumors. Traditionally, Quercetin (Que) based co-delivery drugs strategies show lower water solubility and lack of motion ability for drugs active transfer. In order to overcom...

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Bibliographic Details
Published inColloids and surfaces. A, Physicochemical and engineering aspects Vol. 658; p. 130654
Main Authors Zhou, Haofei, Yuan, Ye, Wang, Zhexu, Ren, Zexin, Hu, Mixia, Lu, JingKun, Gao, Hongxia, Pan, Cheng, Zhao, Wenjie, Zhu, Baohua
Format Journal Article
LanguageEnglish
Published Elsevier B.V 05.02.2023
Subjects
Apoptosis analysis
Drug delivery
Janus nanomotor
Multidrug resistance
Drug delivery
Apoptosis analysis
Janus nanomotor
Multidrug resistance
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Summary:Multidrug resistance (MDR) greatly hinders the efficacy of chemotherapy in a variety of hematological malignancies and solid tumors. Traditionally, Quercetin (Que) based co-delivery drugs strategies show lower water solubility and lack of motion ability for drugs active transfer. In order to overcome this disadvantage, we have developed a Janus nanomotors Pt@HSNs(DQ) for targeted combination therapy. The combined strategy could increase the intracellular accumulation of the two drugs (quercetin and doxorubicin) through the high-speed motion of the motor and higher killing rate of Dox on MCF-7/Adr cells by using quercetin. By reversing Dox resistance, Pt@HSNs(DQ), could achieve lower RI values (8.1) and higher RF values (6.8) in MCF-7/Adr cells compared to free Dox, which means Pt@HSNs (DQ) is effective against multidrug resistance. This work exhibits a novel nanoplatform, which could not only load chemotherapy drugs efficiently, but could also improve the effect of chemotherapy drugs by overcoming MDR. [Display omitted]
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2022.130654