Proteomics discovery in children and young adults with HIV identifies fibrosis, inflammatory, and immune biomarkers associated with myocardial impairment

People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with perinatally acquired HIV without clinical card...

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Bibliographic Details
Published inAIDS (London) Vol. 38; no. 7; pp. 1090 - 1093
Main Authors Harrington, Josephine, McCrary, Andrew W, Nguyen, Maggie, Nyandiko, Winstone, Barker, Piers C A, Koech, Myra, Thielman, Nathan M, Muehlbauer, Michael J, Shah, Svati H, Bloomfield, Gerald S
Format Journal Article
LanguageEnglish
Published England Lippincott Williams & Wilkins 01.06.2024
Subjects
Adolescent
Adult
Biomarkers - blood
Child
Female
Fibrosis
Heart Diseases - blood
HIV Infections - complications
Humans
Male
Proteomics
Research Letters
Young Adult
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Summary:People with HIV are at increased risk of cardiac dysfunction; however, limited tools are available to identify patients at highest risk for future cardiac disease. We performed proteomic profiling using plasma samples from children and young adults with perinatally acquired HIV without clinical cardiac disease, comparing samples from participants with and without an abnormal myocardial performance index (MPI). We identified four proteins independently associated with subclinical cardiac dysfunction: ST2, CA1, EN-RAGE, and VSIG2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0269-9370
1473-5571
1473-5571
DOI:10.1097/QAD.0000000000003879