Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp

With a new method called "Action Potential-Clamp" (APC) we studied in single SA nodal cells the contribution of both transient and long lasting calcium currents (L-type and T-type) to the action potential. Action potentials were recorded by a computer and a representative cycle was subsequ...

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Bibliographic Details
Published inPflügers Archiv Vol. 413; no. 6; p. 599
Main Authors Doerr, T, Denger, R, Trautwein, W
Format Journal Article
LanguageEnglish
Published Germany 01.04.1989
Subjects
Action Potentials
Animals
Calcium - physiology
Cells, Cultured
Rabbits
Sinoatrial Node - physiology
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Summary:With a new method called "Action Potential-Clamp" (APC) we studied in single SA nodal cells the contribution of both transient and long lasting calcium currents (L-type and T-type) to the action potential. Action potentials were recorded by a computer and a representative cycle was subsequently repetitively replayed to the same cell under voltage clamp. Blockade of the L-type calcium current (D600) or T-type calcium current (nickel) revealed the quantitative and time related contributions of these currents to the action potential, since the blocked current is compensated by the clamp amplifier.
ISSN:0031-6768
DOI:10.1007/BF00581808