Case report: Complete pathologic response with first-line immunotherapy combination in a young adult with massive liver dissemination of mismatch repair-deficient metastatic colorectal cancer: Immunological and molecular profiling

The current level of evidence for immunotherapy in previously untreated microsatellite unstable metastatic colorectal cancer is based on recent pieces of evidence of few studies that demonstrated durable response and clinical benefit, in terms of objective response rate, disease control rate, and pr...

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Published inFrontiers in oncology Vol. 12; p. 964219
Main Authors Bergamo, Francesca, Dalla Santa, Silvia, Loupakis, Fotios, Cerma, Krisida, Tosi, Anna, De Grandis, Caterina, Dalla Pietà, Anna, Gringeri, Enrico, Angerilli, Valentina, Ramondo, Gaetano, Rago, Alessandro, Cecchi, Fabiola, Benz, Stephen, Cillo, Umberto, Dei Tos, Angelo Paolo, Zagonel, Vittorina, Fassan, Matteo, Rosato, Antonio, Lonardi, Sara
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.12.2022
Subjects
colorectal cancer
complete pathological response
ipilimumab
MSI-H
nivolumab
Oncology
complete pathological response
colorectal cancer
nivolumab
MSI-H
ipilimumab
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Summary:The current level of evidence for immunotherapy in previously untreated microsatellite unstable metastatic colorectal cancer is based on recent pieces of evidence of few studies that demonstrated durable response and clinical benefit, in terms of objective response rate, disease control rate, and progression-free survival in this subgroup of patients. On the basis of combinatorial immunotherapy with nivolumab plus ipilimumab, we report the exceptional case of a complete pathological response in a 21-year-old woman presenting a clinically aggressive stage IV colorectal cancer with massive nodal and liver involvement. Extensive molecular analyses based on whole genome next-generation DNA sequencing, RNA sequencing, fluorescent multiplex immunohistochemistry, and flow cytometry provided a detailed description of tumoral and immunological characteristics of this noteworthy clinical case.
Bibliography:Edited by: Andrea Sartore-Bianchi, University of Milan, Italy
This article was submitted to Gastrointestinal Cancers: Colorectal Cancer, a section of the journal Frontiers in Oncology
These authors have contributed equally to this work and share senior authorship
These authors have contributed equally to this work and share first authorship
Reviewed by: Michael White, University of Texas MD Anderson Cancer Center, United States; Federica Marmorino, University of Pisa, Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.964219