Quantitative analysis of piroxicam polymorphs pharmaceutical mixtures by hyperspectral imaging and chemometrics

It has been recognized that crystal polymorphism is an important factor related to the physicochemical and biological properties of drug substances and formulations. In this work, the piroxicam polymorphic forms 1 and 2 were studied using near-infrared chemical imaging (NIR-CI) technology to map the...

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Bibliographic Details
Published inChemometrics and intelligent laboratory systems Vol. 106; no. 2; pp. 198 - 204
Main Authors Fortunato de Carvalho Rocha, Werickson, Sabin, Guilherme Post, Março, Paulo Henrique, Poppi, Ronei Jesus
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.04.2011
Subjects
Hyperspectral imaging
Partial least squares
Piroxicam
Polymorphism
Piroxicam
Partial least squares
Polymorphism
Hyperspectral imaging
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Summary:It has been recognized that crystal polymorphism is an important factor related to the physicochemical and biological properties of drug substances and formulations. In this work, the piroxicam polymorphic forms 1 and 2 were studied using near-infrared chemical imaging (NIR-CI) technology to map the distribution of both species in pharmaceutical formulations. In this direction, the partial least squares (PLS) method was used to construct calibration models of concentrations per pixel of the sample. The RMSEP results for both models of the polymorphic forms remained below 4% (w/w). It was also possible to distinguish local and global information of the constituents through this method. These results seem to be a suitable tool for quality process control and final product quality assurance.
ISSN:0169-7439
1873-3239
DOI:10.1016/j.chemolab.2010.04.015