Synthesis and antimycobacterial activity of some steroidal derivatives of tigogenin

Some 5α-type steroidal derivatives of the steroidal sapogenin tigogenin were synthesized. The structures of the synthesized derivatives were characterized by spectral methods and elemental analysis. The antituberculosis activity of the compounds toward Mycobacterium tuberculosis strain H37Rv was stu...

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Published inChemistry of natural compounds Vol. 45; no. 3; pp. 389 - 392
Main Authors Merlani, M. I, Amiranashvili, L. Sh, Kemertelidze, E. P, Mulkidzhanyan, K. G
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 2009
Springer US
Springer Nature
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Life Sciences & Biomedicine
Medicine
Organic Chemistry
Pharmacology & Pharmacy
Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
antimycobacterial activity
5α-aminosteroids
5α-steroidal hydrazones
MYCOBACTERIUM-TUBERCULOSIS
5 alpha-steroidal hydrazones
5 alpha-aminosteroids
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Summary:Some 5α-type steroidal derivatives of the steroidal sapogenin tigogenin were synthesized. The structures of the synthesized derivatives were characterized by spectral methods and elemental analysis. The antituberculosis activity of the compounds toward Mycobacterium tuberculosis strain H37Rv was studied in vitro (Microplate Alamar Blue Assay) in BACTEC 12B medium and was compared with that of isoniazide. Some of the synthesized compounds exhibited high (92-98%) antimycobacterial activity.
Bibliography:http://dx.doi.org/10.1007/s10600-009-9335-9
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-009-9335-9